Background: Increasing resistance of Pseudomonas aeruginosa to ciprofloxacin in ICU/burn units has created a problem in the treatment of infections caused by this microorganism. -/- Methods: Fifty P. aeruginosa strains were isolated from burn patients hospitalized in the Kerman Hospital during May 1999-April 2000 and were tested for in-vitro sensitivity to different antibiotics by disc diffusion breakpoint assay. The isolates were subjected to minimum inhibitory concentration (MIC) test by agar dilution method. Existence of the plasmids was also investigated in the (...) isolates. -/- Results: Thirty-four patients infected with ciprofloxacin strains showed MIC of 8 mg/ml [p<0.001]. Sixteen patients were infected with sensitive strains exhibiting MIC range of 0.0125-0.125 ± 0.033 mg/ml. The isolates were also also resistant to other antibiotics [p<0.001]. Plasmid isolation and agarose gel electrophoresis (0.7%) revealed three plasmid bands in strains 8 and 16, and one band in strain 35. -/- Conclusion: The emergence of ciprofloxacin resistance of P. aeruginosa in burn patients is alarming since this antibiotic has only recently been introduced onto the market in Iran. One important observation was that some isolates exhibited cross resistance to other antibiotics. Furthermore, some strains were carriers of plasmids which might have acted as the potential source of acquired resistance in the hospital setting. -/- . (shrink)

A unifying theory of general anesthetic-induced unconsciousness must explain the common mechanism through which various anesthetic agents produce unconsciousness. Functional-brain-imaging data obtained from 11 volunteers during general anesthesia showed specific suppression of regional thalamic and midbrain reticular formation activity across two different commonly used volatile agents. These findings are discussed in relation to findings from sleep neurophysiology and the implications of this work for consciousness research. It is hypothesized that the essential common neurophysiologic mechanism underlying anesthetic-induced unconsciousness is, as with (...) sleep-induced unconsciousness, a hyperpolarization block of thalamocortical neurons. A model of anesthetic-induced unconsciousness is introduced to explain how the plethora of effects anesthetics have on cellular functioning ultimately all converge on a single neuroanatomic/neurophysiologic system, thus providing for a unitary physiologic theory of narcosis related to consciousness. (shrink)

We generalize two well-known model-theoretic characterization theorems from propositional modal logic to first-order modal logic. We first study FML-definable frames and give a version of the Goldblatt–Thomason theorem for this logic. The advantage of this result, compared with the original Goldblatt–Thomason theorem, is that it does not need the condition of ultrafilter reflection and uses only closure under bounded morphic images, generated subframes and disjoint unions. We then investigate Lindström type theorems for first-order modal logic. We show that FML has (...) the maximal expressive power among the logics extending FML which satisfy compactness, bisimulation invariance and the Tarski union property. (shrink)

In the coverage of the problems of war and peace in Catholicism, researchers sometimes omit the regional component of their manifestation. We are talking about local traditions in Catholicism, which have their own specific approach to solving this problem and sometimes may differ significantly from the "conventional" position. The study of this field is necessary because in the delineated field the position of those theologians who were on the "outskirts" of Catholicism in the intercultural dialogue, on the one hand, led (...) to a deviation from the humanistic orientation about Catholicism. the war. An example would be the concept of a "holy war" of the Crusades, which had the anti-Islamic rhetoric generated not only in the West but also in the East. (shrink)

This special issue of Journal of Consciousness Studies brings together work from a range of philosophers, neuroscientists, psychologists, cognitive scientists, behavioural scientists, and computer scientists who are all united in their approach to answering questions about consciousness. The contributions to this journal are inspired by work presented at the inaugural Designed Mind Symposium, held at the University of Edinburgh Informatics Forum on 7-8 November 2017.

This is my first systematic publication on fearism. It is a general theoretical study but does not itself remain un-affected. Based on experience and theorizing on fearism, I am convinced it is a deeply terrifying encounter, as would be the encounter critically of any harmful violent ideology. Fearism, arguably, is the most terrifying to encounter, which no doubt explains why it has not been spoken about in human history so directly until only this last decade....

The premise behind this paper is that "we" have a very serious Fear Problem. As a stream of inquiry in the larger In Search of Fearlessness Movement, the author pursues a long lingering question and concern about how the West has near neglected the call to examine "fearlessness" in contradistinction to the East. With the purpose to build a better understanding of fearlessness, theories about it, and how it fits into the author's most recent turn to co-developing a philosophy of (...) fearism.... (shrink)

In this paper, I argue for the modest claim that people's apparent indifference to animal pain may not be predicated upon speciesism. I defend that claim by developing an analogy between current attitudes toward at least some non‐human animal pain — that which pigs endure while having their tails ‘docked’— and our culture's indifference to the pain that male human infants experience while being circumcised. And I conclude that to convince more of their philosophical and social critics, ‘animal liberationists’ need (...) to spend more time analyzing the pain that non‐human animals experience and defending its moral significance, rather than assuming that such pain is significant and then simply arguing that unnecessary forms of it exist. (shrink)

The aim of this study was to test red - green dichromats' ability to discriminate between illuminant and surface-reflectance changes in natural scenes. Stimuli were simulations of natural scenes presented on a colour monitor with 10-bit resolution per gun. The natural scenes were obtained with a fast hyperspectral imaging system. Six different scenes (including rocks, foliage, and buildings) were tested. In each trial, two images were presented in sequence, each for 1 s, with no interval. The images differed in the (...) phase of daylight on the scene: first with correlated colour temperature 25 000 K, then 6 700 K. The spectral reflectance of a region in the second image was changed randomly, consistent with a local change in daylight. The observer's task was to decide whether a particular surface in the successive images was the same (pure illuminant change) or different (illuminant change with a surface-reflectance change). The performance of four deuteranopes and five protanopes varied considerably across the scenes tested, with mean colour constancy indices (± 1 SEM) of 0.48 (± 0.13) and 0.19 (± 0.10), respectively (1.0 representing ideal performance). Deuteranopes seemed less disadvantaged than protanopes, performing close to normal with some scenes. (shrink)

In a recently-published work of much learning and great interest, La Frontière de l'Euphrate de Pompée à la Conquète Arabe , M. Victor Chapot has dealt at some length with the history of the eastern legions. But neither he, nor, so far as I can find, any other writer, has attempted to fix their camps with full regard to chronology, and many points have been left uncertain. Although there is little direct evidence—less than for any other part of the Roman (...) Empire—it may be possible to construct with reasonable probability a more exact military map of the eastern frontier. (shrink)

Long time delay before lasing in a II-VI laser diode has been observed. Due to this delay, a nominal threshold current increases as the width of applied current pulse becomes shorter. This delay is attributed to the internal Q switching caused by the balance of injected carriers, temperature rise and gain-guiding. By fitting the calculated data to the experimental ones, rates of refractive index change with carrier concentration and with temperature have been estimated.

The work of Sinden et al. suggests that it may be possible to produce improvement in the areas of brain function by transplanting brain tissue. What appears to be the limiting factor is not the complexity of the mental process under consideration but the discreteness of the lesion which causes the impairment and the appropriateness and accuracy of placement of the grafted tissue.

First Edition 1995, Second Edition 2012.